Abraham Model Descriptors for Melatonin; Prediction of Solution, Biological and Thermodynamic Properties

Abstract Literature solubilities have been used to obtain properties or descriptors of melatonin. These indicate the chemical nature melatonin: it is dipolar and has moderate hydrogen bond acidity basicity. The can be combined with equations that we previously constructed estimate water–solvent partition coefficients in a huge number organic solvents. In same way, range biological estimated. include blood–tissue partitions, water–skin permeability through skin.